I'm attempting to make 64-bit Windows Vista by primary OS, now that I have the RTM build, at last (thanks Microsoft)! As I march though the tedious process of installing all my critical apps, I have encountered very few Vista-related compatibility issues. Unfortunately, I have discovered quite a few x64-related issues (I never tried XP x64). Here's my wish list of software that will hopefully be updated with Vista x64 support in the near future:
I'll update the list if I find any more issue (hopefully not).